Worked at University of Illinois at Chicago and at University of California, Davis, U.S.A. during 1986-87, Marie Curie Fellow of European Union in 1994,1996 and worked at Lancaster University, Lancaster, UK, DAAD Fellow in Bonn University, Germany in 1997 and 1998, UNDP Fellow at Biological Research Centre, Hungarian Academy of Sciences, Szeged, (1978-1979) and 1982 and WHO Fellow at the Institute of Microbiology, Czechoslovakia Academy of Sciences, Praha, Czecholovakia in 1983. He has served as Professor of Microbiology and Biotechnology, Barkatullah University, Bhopal (1985 - 2001), Vice-Chancellor Jiwaji University, Gwalior (1994 to 1996), Dean, Academic, Planning and Development, Bundelkhand University, JHANSI, (U.P.) June 2004 to July 2005. Director, Madhav Institute of Technology and Science, Gwalior, (2001 - June 2004). Since 2007, Professor Bisen is an Honorary Professor of Biotechnology at Jiwaji University, Gwalior, India.
Presently, Professor Prakash Singh Bisen is the Chairman of Bisen Biotech and Biopharma (P) Ltd. - a private equity venture which focuses on diagnostic solutions for widespread diseases. Professor Bisen is also the Chairman of the Vikrant Group, which focuses on advancing technical education through technical institutes at Gwalior and Indore, India.